Neurotrophic Factors and Depression: Pathophysiology and Beyond
نویسندگان
چکیده
Ya zış ma Ad re si / Add ress rep rint re qu ests to: Feyza Arıcıoğlu Marmara Üniversitesi Eczacılık Fakültesi, Farmakoloji Anabilim Dalı ve Psikofarmakoloji Araştırma Birimi, Haydarpaşa, 34668, İstanbul-Türkiye Telefon / Phone: +90-216-418-9573 Faks / Fax: +90-216-345-2952 Elektronik posta adresi / E-mail address: [email protected] Ka bul ta ri hi / Da te of ac cep tan ce: 28 Mayıs 2012 / May 28, 2012
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Lithium treatment alters brain concentrations of nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor in a rat model of depression.
Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) are proteins involved in neuronal survival and plasticity of dopaminergic, cholinergic and serotonergic neurons in the central nervous system. Since decreased size and impaired function of some neuronal populations may be relevant in depression it has been hypothesized that...
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